Decoupling transcription factor expression and activity enables dimmer switch gene regulation

RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation

T cell fate is associated with mutually exclusive expression of CD4 or CD8 in helper and cytotoxic T cells, respectively. How expression of one locus is temporally coordinated with repression of the other has been a long-standing enigma, though we know RUNX transcription factors activate the Cd8 locus, silence the Cd4 locus, and repress the Zbtb7b locus (encoding the transcription factor ThPOK)...

Decoupling of evolutionary changes in transcription factor binding and gene expression in mammals.

To understand the evolutionary dynamics between transcription factor (TF) binding and gene expression in mammals, we compared transcriptional output and the binding intensities for three tissue-specific TFs in livers from four closely related mouse species. For each transcription factor, TF-dependent genes and the TF binding sites most likely to influence mRNA expression were identified by comp...

Study of MYB Transcription Factor Gene Expression in Some Bread Wheat Cultivars of Sistan Region, Iran

Drought, an abiotic stress, considered as one of the factors limiting food resources. The plant responses to adaptive to such a condition are accompanied with changes in the expression pattern of some functional as well as regulatory genes. The MYB proteins include a big family of transcription factors which are highly important in regulating development process and immunizing responses of plan...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

Reactive oxygen species level, mitochondrial transcription factor A gene expression and succinate dehydrogenase activity in metaphase II oocytes derived from in vitro cultured vitrified mouse ovaries

The aim of this study was to evaluate the effects of ovarian tissue vitrification and two-step in vitro culture on the metaphase II (MII) oocyte reactive oxygen species (ROS) level, mitochondrial transcription factor A (TFAM) expression and succinate dehydrogenase (SDH) activity. After collection of neonatal mouse ovaries, 45 ovaries were vitrified and the others (n = 45) were...